Yes, but you'll need to embed a dynamic typing scheme to do it. With dynamic types in place, an overriding method in a derived class can explicitly check argument types in a switch statement and invoke the desired method emulating multiple-polymorphism [See Coplien 92].
For true CLOS multi-methods, the above technique implemented as a base function (CLOS defgeneric), switching to specialized functions (CLOS methods, made friends of all arguments) will provide the functional calling syntax, multiple- polymorphism and access to parameters found in CLOS. This can require some complex switching, which is somewhat mitigated when multiple-polymorphism is implemented with virtual functions.
Future FAQs should contain more detail.
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